BCL2L1 antibody (AA 89-151)

Catalog No. ABIN1886696

The Rabbit Polyclonal anti-BCL2L1 antibody has been validated for WB, IHC and IF. It is suitable to detect BCL2L1 in samples from Human.

Quick Overview for BCL2L1 antibody (AA 89-151) (ABIN1886696)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-BCL2L1 Antibody

Binding Specificity: AA 89-151

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 89 and 151 of Human BCL2L1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Alternative Name: BCL2L1

Background: The protein encoded by this gene belongs to the BCL-2 protein family.BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening.VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.[provided by RefSeq]

Molecular Weight: 19 kDa

Gene ID: 598

NCBI Accession: NP_001182, NM_001191

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling